Aortic Aneurysm, Abdominal, Popliteal Artery Aneurysm
Conditions
Keywords
Abdominal aortic aneurysm, Popliteal aneurysm, Screening
Brief summary
Observational, prospective, cohort study to evaluate, by an opportunistic screening program based on vascular ultrasound, the prevalence and characteristics of Abdominal Aortic Aneurysm (AAA) and Popliteal Artery Aneurysm (PAA) in a female population as well as the prevalence and characteristics of PAA in male population.
Detailed description
Abdominal aortic aneurysm (AAA) remains a highly topical issue given the potentially dramatic consequences associated with its rupture. In men, the prevalence of AAA is declining, probably due to improved management of risk factors. However, the most recent studies and international recommendations have reaffirmed that screening for AAA in men is still important and cost-effective. In contrast, data regarding the risk and characteristics of AAA in women are very limited and outdated. For this reason, the recommendations are contrasting and not univocal. About 35% of patients with AAA have a second aneurysm more distally. Popliteal artery aneurysm (PAA) is the most common. Like AAA, PAA is often asymptomatic and its main complication is thrombotic occlusion resulting in acute/chronic ischemia of the affected limb and a high prevalence of permanent sequelae (mainly amputation). Data on epidemiology and risk factors of PAA are very limited in men and absent in women. In addition, the benefit of PAA screening has never been assessed so far. The aim of this study is to evaluate, by an opportunistic screening program based on vascular ultrasound, the prevalence and characteristics of AAA and PAA in a female population as well as the prevalence and characteristics of PAA in male population. The project represents the first screening program for popliteal aneurysm. Finally, the results will allow us to better assess need for and modalities of a screening program.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire Vaudois
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Women aged ≥65 years who are current smokers * Men aged ≥65 years * Women or Men aged ≥55 years with family history (first-degree relatives) for Abdominal Aortic Aneurysm (AAA) or popliteal artery aneurysm (PAA)
Exclusion criteria
* Patient with known diagnosis of AAA or PAA * Patient already operated for AAA or PAA * AAA/PAA screening or arterial assessment of lower limbs within the last 12 months * Inability to understand and/or sign study consent * Inability to access follow-up controls
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Abdominal aortic measurement | 1 day | Ultrasound of infrarenal aorta with diameter measured in mm |
| Popliteal artery measurement | 1 day | Ultrasound of popliteal artery with diameter measured in mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Smoking habits | 1 day | Defined by active smoking, former smoking, never smoking |
| Other cardiovascular risk factors | 1 day | Arterial hypertension, Diabetes, Dyslipidemia, Obesity |
| History of cardiovascular diseases | 1 day | Coronary artery disease, cerebrovascular disease, lower extremity peripheral artery disease, venous thromboembolism |
| Family history for aneurysmal disease | 1 day | First-degree relatives with aneurysmal disease |
| Time-consuming | 1 day | Time needed to perform screening |
| Surgical intervention for aneurysm | 36 months | Number of aneurysm operated during follow-up |
Countries
Italy, Switzerland
Contacts
STUDY_CHAIRLucia Mazzolai, MD, PhD
Centre Hospitalier Universitaire Vaudois
PRINCIPAL_INVESTIGATORAdriano Alatri, MD
Centre Hospitalier Universitaire Vaudois
Outcome results
None listed