Functional Prognosis of Post-operative Patients With Cerebral Small Vascular Disease(CSVD)

Association Between Postoperative Cerebral Vascular Complication and Functional Prognosis and Cerebral Small Vascular Disease (CSVD) After Thoracic Surgery : an Exploratory Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05359588

Enrollment

212

Registered

2022-05-04

Start date

2022-01-31

Completion date

2023-01-31

Last updated

2022-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Small Vessel Diseases, Long Term Adverse Effects

Brief summary

The investigators perform a retro-prospective exploratory cohort study among patients 65 to 85 years old with pre-operative head MRI result after thoracic surgery in Renji Hospital Affiliated to Shanghai Jiaotong University from November 2020 to December 2021. Perioperative data were collected, including preoperative general condition, laboratory examination, auxiliary examination (blood routine, blood coagulation, liver and kidney function, etc.), perioperative indicators （use of anesthetics, anesthetic time, blood pressure, etc.）, postoperative cerebral function follow-up and occurrence of cerebral vascular complications (brain infarction, brain bleed, etc.) of patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to 85 Years

Healthy volunteers

Inclusion criteria

* 65≤age\<85 * after thoracic surgery * finish pre-operative brain MRI

Exclusion criteria

* mental illness * existing dementia and other diseases: Alzheimer disease, dementia, Parkinson's disease, Huntington's disease, systemic lupus erythematosus, etc. * previous cerebral infarction or hemorrhage

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative overt stroke	1 year after surgery	Postoperative overt stroke detected by MRI of the brain

Secondary

Measure	Time frame	Description
Physical function after surgery as assessed using Activities of Daily Living (iADL) Scale	1 year after surgery	score of Activity of Daily Living Scale with total score of 78, higher score, better function) and Modified Ranking Scale from 0(no symptomatic post-infarction complication ) to 6 (death after cerebral infaction)
Physical function after surgery as assessed using the Modified Rankin Scale	1 year after surgery	The scale runs from 0-6, running from perfect health without symptoms to death. A higher score is worse.

Countries

China

Contacts

Primary ContactDan Huang

huangdan@renji.com+8615921108822

Outcome results