COVID-19
Conditions
Keywords
SARS-CoV-2, Seroprevalence, IgG Antibodies, Children, Vietnam, Covid-19
Brief summary
It is unknown what proportion of children have been exposed to SARS-CoV-2 and how many have antibodies among children seeking medical care for non-Covid-19 related conditions. The aim of this study is to identify children with IgG antibodies to SARS-CoV-2 who have not been previously diagnosed and are presumed/confirmed Covid-19 negative, then determine the level of immunity in this population which could inform further decisions about covid-19 vaccine strategies for children
Detailed description
Enrolled participants will have a survey about demographic information, history of previous suspected/confirmed Covid-19 infection or exposed to SARS-CoV-2, Covid-19 vaccination status. For participants aged less than 12 months, participants' mothers' status of Covid-19 vaccination and/or previous infection will be recorded. Participants will then complete serologic testing for SARS-CoV-2 IgG antibodies using residual plasma specimens collected/stored for routine laboratory tests on the date of enrollment. The study will characterize the prevalence of antibody positivity in this population and assess whether there is a correlation between demographic characteristics and antibodies levels.
Interventions
DIAGNOSTIC_TESTSARS-CoV-2 IgG Antibody testing
IgG Antibody testing for previous exposure to SARS-CoV-2
Sponsors
National Children's Hospital, Vietnam
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
0 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 18 years old. * Seeking medical care at Vietnam National Children's Hospital for any condition not related to acute Covid-19 * Have not been previously diagnosed and are presumed/confirmed COVID-19 negative * Have blood specimens collected for any routine biochemistry test on the date enrollment
Exclusion criteria
* Refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The percentage of children with IgG SARS-CoV-2 antibodies in Plasma | 6 month | The percentage of children with IgG SARS-CoV-2 antibodies to the total number of children enrolled in the study |
| Immunoglobulins (G) to SARS-CoV-2 in plasma | 6 month | Mean antibody titres (IgG) to SARS-CoV-2 in plasma using SIEMENS assays |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measure of association between SARS-CoV-2 IgG seropositivity and characteristics | 6 month | socio-demographics, previous exposure to SARS-CoV-2 |
Countries
Vietnam
Outcome results
None listed