Brain Metastases, Brain Tumor
Conditions
Brief summary
The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.
Interventions
DIAGNOSTIC_TESTDynamic susceptibility contrast magnetic resonance imaging (DSC MRI)
A dye, known as a contrast agent, will be injected through a needle that is inserted into a vein in the arm or hand. Subsequent magnetic resonance imaging will follow.
Sponsors
University Health Network, Toronto
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast.
Exclusion criteria
* Subject or subject's legally authorized representative is unable or unwilling to consent to the study. * Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of perfusion parameter: vessel size index (VSI) | Baseline to end of study (up to 2 years) | Measurements of vessel size index (VSI) will be calculated. |
| Measurement of perfusion parameter: cerebral blood volume (CBV) | Baseline to end of study (up to 2 years) | Measurements of cerebral blood volume (CBV) will be calculated. |
Countries
Canada
Contacts
Primary ContactAngelica Manalac
Outcome results
None listed