Undifferentiated Round Cell Sarcoma
Conditions
Brief summary
Experimental study with biological material : case series review of clinical and histological data
Detailed description
This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.
Interventions
OTHERdata collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue
Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.
Sponsors
Istituto Ortopedico Rizzoli
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Inclusion criteria
* Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included. * Clinical and outcome information available. * Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available.
Exclusion criteria
* Diagnosis different from undifferentiated round cell sarcomas * Patient with no clinical or outcome information available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| event free survival | baseline | Correlate clinical and pathological variables with event-free survival and overall-survival in undifferentiated round cell sarcomas. |
Countries
Italy
Contacts
Primary ContactEmanuela Palmerini, MD
Backup ContactMarco Gambarotti, MD
Outcome results
None listed