Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder

Feasibility and Preliminary Data on the Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05357521

Acronym

OXT-CORT-BPD

Enrollment

100

Registered

2022-05-03

Start date

2022-03-01

Completion date

2025-04-30

Last updated

2025-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Borderline Personality Disorder, Oxytocin

Keywords

cortisol, tsst, borderline personnality, stress

Brief summary

This study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.

Detailed description

The investigators will recruit 50 female patients with borderline personnality disorder and 50 controls with no psychiatric diagnosis, aged between 18 and 25 years old. salivary cortisol daily curve ( 6 measures during the day) will be measured in participant's naturalistic environnement, together with salivary oxytocin. In addition, salivary oxytocin and cortisol will be measured during a psychosocial stress task and recovery.

Interventions

OTHERstress test

TSST- psychosocial stress test

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Borderline personality disorder-DSM V

Exclusion criteria

* Schizophrenia

Design outcomes

Primary

Measure	Time frame	Description
Salivary cortisol	Baseline	salivary cortisol measured with salivettes (swabs)
Salivary oxytocin	Baseline	salivary oxytocin measured with salivettes (swabs)

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026