Recording of Intraoperative Spinal Cord Stimulation and Monitoring

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05356286

Enrollment

150

Registered

2022-05-02

Start date

2011-01-21

Completion date

2027-01-22

Last updated

2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Stenosis, Disk, Herniated, Spondylosis

Brief summary

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.

Interventions

DEVICEepidural electrical stimulation

Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized.

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame	Description
Change in respiratory frequency	During intraoperative surgery during stimulation and within 2 minutes after stimulation	Increase or decrease in respiratory frequency of 20% during or after stimulation
Change in respiratory tidal volume	During intraoperative surgery during stimulation and within 2 minutes after stimulation	Increase or decrease in respiratory tidal volume of 20% during or after stimulation

Secondary

Measure	Time frame	Description
Change in heart rate	During intraoperative surgery during stimulation and within 2 minutes after stimulation	Increase or decrease in heart rate of 20% during or after stimulation
Change in blood pressure	During intraoperative surgery during stimulation and within 2 minutes after stimulation	Increase or decrease in blood pressure of 20% during or after stimulation

Countries

United States

Contacts

Primary ContactDaniel Lu, MD

dclu@mednet.ucla.edu310/825/4321

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026