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Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure

Vasopressor Utilization to Support Mean Arterial Pressure During Rapid Sequence Intubation: A Clinical Trial (Rapid-Press Trial)

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05355974
Acronym
RAPID PRESS
Enrollment
42
Registered
2022-05-02
Start date
2022-08-09
Completion date
2024-07-10
Last updated
2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication, Anesthesia Intubation Complication

Keywords

mean arterial pressure, Rapid Sequence Intubation, vasopressor, Norepinephrine, Hypotension from Intubation

Brief summary

The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events. The hypothesis is that use of vasopressors during Rapid Sequence Intubation will prevent substantial decreases in blood pressure when compared to normal intravenous fluids.

Detailed description

Aim: Prevent 25-46 percent reduction in systolic blood pressure associated with rapid sequence intubation with norepinephrine compared to isotonic fluids alone.

Interventions

DRUGNorepinephrine

Norepinephrine continuous infusion at 0.10 mcg/kg/min

DRUGLactated Ringers, Intravenous

500mL infusion run at 999mL/hr

DRUGnormal saline

500mL infusion run at 999mL/hr

DRUGPlasma-lyte

500mL infusion run at 999mL/hr

Sponsors

Wright State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Respiratory Failure Requiring Intubation

Exclusion criteria

* Pregnancy * Patients intubated during code blue clinical scenarios * Requiring surgical airway * Failed intubations * MAP less than 65 or Systolic Blood Pressure (SBP) less than 90mmHg pre-intubation * Systolic blood pressure greater than 150mmHg * Prisoners

Design outcomes

Primary

MeasureTime frameDescription
Systolic Blood Pressure1 hour after Rapid Sequence IntubationChange in systolic blood pressure during rapid sequence intubation in mmHg.

Secondary

MeasureTime frameDescription
Change in serum creatinine (Acute Kidney Injury)24 hours after Rapid Sequence IntubationChange in serum creatinine (in mL) after rapid sequence intubation and development of Acute Kidney Injury as defined by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours
Acute Kidney Injury24 hours after Rapid Sequence IntubationChange in urine output (in mL) after rapid sequence intubation and development of Acute Kidney Injury as defined by Urine volume \<0.5 mL/kg/hour for six hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026