Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05355857

Acronym

ATLATEP

Enrollment

Registered

2022-05-02

Start date

2022-08-10

Completion date

2023-03-23

Last updated

2023-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Diseases

Keywords

FDG PET, PET-MRI, atlas, brain

Brief summary

With 18F-FDG PET, we have few atlases of normality allowing the realization of objective quantitative analyses. An atlas of normality is a probabilistic atlas of normal FDG uptake from a representative set of brain PET images of healthy subjects. This type of atlas is essential for intra- and inter-individual comparisons. Accurate quantitative analysis of brain 18F-FDG PET images acquired on a hybrid PET system has been shown to require an institutional normal database for statistical analyzes (Akdemir et al., JNM 2017 and Della Rosa et al Neuroinformatics, 2014).

Detailed description

This is a prospective, monocentric, non-randomized study, with no direct individual benefit since it involved healthy volunteers.

Interventions

DIAGNOSTIC_TESTbrain PET-MRI with 18F-FDG

Realisation of a brain PET-MRI with 18F-FDG in 39 healthy volunteers

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Healthy volunteers

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Male or female aged 20 to 50 * Absence of any history or cardiovascular, neurological or psychiatric deficit * Signed the informed consent

Exclusion criteria

* Contraindication to the realization of an MRI or PET and to the injection of 18F-FDG * People using a pacemaker or insulin pump * People wearing a metal prosthesis or an intracerebral clip * People with intraocular metal splinters * People with a pathology considered incompatible for the production of the atlas according to the investigator * Pregnant women and breastfeeding women * Subject in period of exclusion.

Design outcomes

Primary

Measure	Time frame	Description
Creation, from a representative set of brain PET-MRI images of healthy subjects, of a probabilistic atlas of normal FDG uptake in healthy volunteers	30 minutes after 18F-FDG injection	Evaluation of tracer activity at the cerebral level on the acquisition images

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026