Hepatocellular Carcinoma, Liver Transplantation, Survival
Conditions
Keywords
elderly donor, liver transplantation, donation after cardiac death, hepatocellular carcinoma, survival
Brief summary
Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.
Detailed description
Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.
Interventions
OTHERAge
The study was retrospective and did not involve the application of interventions.
Sponsors
First Affiliated Hospital Xi'an Jiaotong University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Recipient age ≥ 18 years and \< 65 years. 2. Donor age ≥ 18 years.
Exclusion criteria
1. Recipient age \<18 years or ≥65 years. 2. Donor age \<18 years. 3. Patients who died within 30 days after transplantation. 4. Secondary liver transplantation. 5. Multiple organ transplantation. 6. Patients with incomplete data or failed follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence of the primary disease after surgery | The time period between liver transplantation and the initial examination revealing a recurrence of primary disease, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 72 months. | Recurrence of primary disease in patients who underwent liver transplantation after surgery |
| Post-operative survival time | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months. | Postoperative survival time for patients receiving liver transplantation |
| Transplanted liver status | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.The functional status of the transplanted liver was recorded during this period. | Postoperative Liver Function in Patients Undergoing Liver Transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgery details | Intraoperative | Detailed information such as operation time |
| Post-operative complications in patients who underwent liver transplantation | Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.During this period, all postoperative complications of the patient will be recorded. | Specific details of all post-operative complications in patients who underwent liver transplantation |
Outcome results
None listed