Vestibular Disorder Preservation
Conditions
Keywords
dexamethasone, gentamicin
Brief summary
Intractable symptoms of Meniere's disease will be treated with intratympanic steroids. At the same time intratympanic dexamethasone will be used to rescue hearing
Detailed description
For Alleviation of Intractable symptoms of Meniere's disease will be treated with intratympanic steroids. Measured with pre and post therapy vestibular severity index. At the same time intratympanic dexamethasone will be used to rescue hearing measured with speech reception threshold and speech discrimination threshold
Interventions
DRUGGentamicin
Intratympanic gentamicin and dexamethasone administered in two doses one week apart
DRUGDexamethasone
Intratympanic gentamicin and dexamethasone administered in two doses one week apart
Sponsors
Combined Military Hospital Quetta
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
For Alleviation of Intractable symptoms of Meniere's disease will be treated with intratympanic steroids. Measured with pre and post therapy vestibular severity index. At the same time intratympanic dexamethasone will be used to rescue hearing measured with speech reception threshold and speech discrimination threshold
Intervention model description
Patients with unilateral Meniere's disease with intractable vertigo will be administered two doses of intratympanic gentamicin plus dexamethasone 1 week apart
Eligibility
Sex/Gender
ALL
Age
24 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients of unilateral Meniere's disease with severe vestibular symptoms
Exclusion criteria
* Bilateral disease, operated cases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vestibular Rehabilitation | Three months | Improvement in vestibular severity index |
Countries
Pakistan
Contacts
Primary ContactZeeshan Ayub, FCPS
Backup ContactZeeshan Ayub, FCPS
Outcome results
None listed