Intensive Care Units, Pediatric
Conditions
Brief summary
Currently, recommendations for antibiotic testing (ATS) in adult intensive care have been published. The 2018 SFAR and the Abdul- Aziz et al expert conference recommend routine testing for β-lactams, aminoglycosides, linezolid, and vancomycin and provide plasma concentration goals. No recommendations have been made for the pediatric intensive care unit (PICU) population. However, several articles report suboptimal plasma concentrations for the most frequently used antibiotics in PICU. The University Hospital of Reunion is the reference center for the western region of the Indian Ocean. This region presents a large mixed population due to the migratory flow, as well as a specific bacterial ecology. This suggests that the data already collected on antibiotic dosage in other European studies may not be fully extrapolated to Reunion Island. It is in this context that we will study the plasma concentration of antibiotics for all children who received the most commonly used antibiotics (β-lactams, linezolid, vancomycin, and aminoglycosides) during their hospitalization in PICU.
Interventions
OTHERAntibiotics Dosing
Dosing concerns the main antibiotics used in the unit: b-lactams, linezolid, vancomycin and aminosides
Sponsors
Centre Hospitalier Universitaire de la Réunion
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Any child hospitalized in the pediatric intensive care unit of the CHU Nord de La Réunion, * Age is less than 18 years, * Having started a curative antibiotic therapy by β-lactam, linezolid, vancomycin or aminosides. * For whom a non-opposition has been collected orally from both or one of the child's legal guardians and from the child himself (if applicable), * Covered by Social Security.
Exclusion criteria
-Patients on prophylactic antibiotic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The occurrence of at least one underdosing event of one of the Antibiotics used in a patient included during his or her hospitalization in pediatrics intensive care unit (PICU) | 2 months | Underdosing is defined as a measurement of plasma concentration below the optimal therapeutic concentration (OTC) |
Countries
Reunion
Contacts
Primary ContactLise PEIPOCH, MD
Backup ContactLaetitia BERLY, PhD
Outcome results
None listed