STEMI - ST Elevation Myocardial Infarction
Conditions
Brief summary
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. In indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels.
Detailed description
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. In indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels. The purpose of this study was to compare the time from first medical contact to patency and safety (specifically symptom improvement, ECG ST segment) between intravenous thrombolysis and concurrent patients with possible primary PCI in a prospective, multicenter, non-randomized controlled manner. Significant fall, angiographic examination showed criminal blood vessel TIMI blood flow grade 2-3)
Interventions
DRUGThrombolytic
Standard intravenous thrombolysis.
PROCEDUREpercutaneous coronary stenting
Percutaneous coronary stenting
Sponsors
Ya-Wei Xu
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
non-randomized control
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* ECG confirms acute ST-segment elevation myocardial infarction；The estimated time from FMC to recanalization is more than 120 minutes；
Exclusion criteria
* Intracranial hemorrhage or stroke within the past 6 months; central nervous system injury, tumor or arteriovenous malformation; bleeding disease with known cause; suspected aortic dissection; non-compressible puncture surgery within 24 hours, etc.; 1 week of pregnancy or postpartum; uncontrolled hypertension; advanced liver disease; active peptic ulcer; prolonged or invasive CPR;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| recanalization | within 24 hours | Coronary angiography to check for recanalization after thrombolysis（Yes or No） |
| recanalization time | within 2 hours | From first medical contact(FMC) time to recanalization time. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major bleeding event | 7 day | Whether there is a major bleeding event with drug thrombolysis（Yes or No） |
| Malignant arrhythmia | 12 hours | Malignant arrhythmia incidence |
Countries
China
Contacts
Primary ContactJun Zhang, Doctor
Outcome results
None listed