Idiopathic Pulmonary Fibrosis, IPF
Conditions
Keywords
idiopathic pulmonary fibrosis, inspiratory muscle training, home-based, rehabilitation
Brief summary
The aim of this study is to investigate the effects of the home-based inspiratory muscle training program on lung functions, dyspnea, inspiratory muscle strength, functional capacity and quality of life in patients with idiopathic pulmonary fibrosis. Patients are evaluated before the inspiratory muscle training and after 8 weeks of training.
Detailed description
The IMT protocol consisted of home-based high-intensity daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an IMT Threshold device (Threshold IMT Philips® Respironics, Inc). The intensity of the training was set to 50% of each patient's maximal inspiratory pressure measured every week and was adjusted weekly based on the modified Borg scale from 4 to 6 regarding respiratory effort performed during the session. Patients are evaluated before the inspiratory muscle training and after 8 weeks of training.
Interventions
DEVICEInspiratory Muscle Training (IMT)
The IMT protocol will consist of home-based high-intensity daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an IMT Threshold device (Threshold IMT Philips® Respironics, Inc). The intensity of the training will be set to 50% of each patient's maximal inspiratory pressure measured every week and was adjusted weekly based on the modified Borg scale from 4 to 6 regarding respiratory effort performed during the session.
DEVICESham IMT
The IMT protocol will consist of home-based daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an IMT Threshold device (Threshold IMT Philips® Respironics, Inc). The intensity of the training will be set to the lowest intensity of the IMT Threshold device.
Sponsors
Dokuz Eylul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
This study was designed as a prospective and experimental study. Participants were randomly divided into two groups; a study group and a control group. The study group will perform inspiratory muscle training at 50% of maximal inspiratory pressure (MIP), and the control group received sham training for 8 weeks.
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosing Idiopathic Pulmonary Fibrosis by a pulmonologist; * Aged between 40 and 75 years; * Volunteering to research; * Stable clinical condition (same medication routine and/or no acute exacerbation in the last for the last 4 weeks).
Exclusion criteria
* Inability of the participant to understand or perform the procedures proposed during the evaluations or training program. * Participating in any pulmonary rehabilitation programs; * A previous pneumonectomy or lobectomy operation; * Pneumonia in the last 4 weeks; * Any pulmonary infection during the study; * Requirement for supplemental oxygen therapy while resting. * Having Covid-19 disease (during the study or in the past) * Orthopaedic or neurological conditions affecting the ability to independent walking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in inspiratory muscle strength | 8 weeks | MIP |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in percentages of forced expiratory volume in one second | 8 weeks | Lung function tests: Percentages of forced expiratory volume in one second (FEV1). |
| Change in percentages of forced vital capacity | 8 weeks | Lung function tests: Percentages of forced vital capacity (FVC). |
| Change in diffusing capacity of the lung for carbon monoxide | 8 weeks | Lung function tests: Diffusing capacity of the lung for carbon monoxide (DLCO). |
| Change in Dyspnea | 8 weeks | The modified Medical Research Council (mMRC) Dyspnea Scale was used to evaluate the severity of dyspnea. Commonly used in the assessment of dyspnea in COPD, mMRC has a five-level scoring system ranging from 0 to 4. A high score indicates an increased sense of dyspnea. |
| Change in Functional capacity | 8 weeks | Maximal distance in 6 minute walk test |
Countries
Turkey (Türkiye)
Outcome results
None listed