Compressive Optic Neuropathy, Hereditary Optic Neuropathies, Ischemic Optic Neuropathy, Optic Neuritis, Toxic Optic Neuropathy, Traumatic Optic Neuropathy
Conditions
Keywords
optic neuropathies, visual evoked potential
Brief summary
The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
Detailed description
In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.
Interventions
Magnetic resonance diffusion tensor imaging of the brain
Electrophysiology of the visual pathway.
Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision)
Sponsors
Study design
Intervention model description
Two groups: volunteers with neuropathies and healthy volunteers
Eligibility
Inclusion criteria
Optic neuropathy.
Exclusion criteria
common contraindications to MRI (presence of pacemaker, non-MRI-safety or claustrophobia)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sigma parameter | one month | sigma parameter in our algorithm provides a quantitative measure of nerve atrophy |
Countries
Poland