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Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05353413
Enrollment
20
Registered
2022-04-29
Start date
2020-01-01
Completion date
2024-01-01
Last updated
2022-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Compressive Optic Neuropathy, Hereditary Optic Neuropathies, Ischemic Optic Neuropathy, Optic Neuritis, Toxic Optic Neuropathy, Traumatic Optic Neuropathy

Keywords

optic neuropathies, visual evoked potential

Brief summary

The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging

Detailed description

In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.

Interventions

DEVICENeuroimaging

Magnetic resonance diffusion tensor imaging of the brain

DIAGNOSTIC_TESTVEP - visual evoked potential

Electrophysiology of the visual pathway.

DIAGNOSTIC_TESTOphthalmology examination.

Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision)

Sponsors

University of Bialystok
CollaboratorOTHER_GOV
Medical University of Bialystok
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Outcomes Assessor)

Intervention model description

Two groups: volunteers with neuropathies and healthy volunteers

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Optic neuropathy.

Exclusion criteria

common contraindications to MRI (presence of pacemaker, non-MRI-safety or claustrophobia)

Design outcomes

Primary

MeasureTime frameDescription
sigma parameterone monthsigma parameter in our algorithm provides a quantitative measure of nerve atrophy

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026