Blood Pressure
Conditions
Keywords
Blood pressure, Salt sensitivity
Brief summary
This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.
Interventions
BEHAVIORALYoga
Yoga sessions will be completed 5 times per week for 4 weeks.
BEHAVIORALWaitlist control
Waitlisted participants will maintain their normal exercise and diet for 4 weeks. After follow up testing at week 4, participants will be rerandomized to the yoga condition.
Sponsors
Texas State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* African American * Adults ages 18-60 years
Exclusion criteria
* pregnancy or within 60 days postpartum * having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation); * infection (viral or other) within the past 4 weeks; * having adrenal or endocrine tumors (these could impact BP); * renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated); * prior myocardial infarction; vii) known coronary heart disease; * personal history of stroke; * heart failure; * cardiac arrhythmias; * chronic obstructive pulmonary disease; * recent chest pain or dyspnea; * orthopedic limitations that preclude the execution of yoga postures; * current insulin dependence; * currently taking steroid medications; * currently undergoing chemotherapy or radiation; * having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months; * heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood pressure from low- to high-sodium dietary conditions | Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions. | Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake. |
| Change in endothelial function from low- to high-sodium dietary conditions. | Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4. | Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions. |
| Change in arterial stiffness from low- to high-sodium dietary conditions. | Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4. | Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in urinary sodium excretion from low- to high-sodium dietary conditions. | Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4. | 24-hour urine collection will be completed after 3 days of low- and after 3 days of high-sodium dietary conditions. |
Countries
United States
Outcome results
None listed