Propofol, Glioma, Auditory Event-related Potential (AERP), Electroencephalogram (EEG), Brain Network Connectivity
Conditions
Brief summary
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity. Most of the current anesthesia depth monitoring methods are based on healthy brain function population，which is difficult to reflect the sedation depth of glioma patients accurately. Therefore, this study aims to explore the characteristics of brain network connectivity in glioma patients under different sedation depths by electroencephalogram (EEG) and auditory event-related potential (AERP) methods, which may provide a research basis for sedative titration and anesthesia depth identification in glioma patients.
Interventions
1% propofol is used for target-controlled infusion, and gradually increase the effect concentration at 0.2ug/ml. Make the subject's sedation depth reach light sedation and deep sedation respectively. EEG data were collected during wakefulness, light sedation, deep sedation, and recovery.
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age 18 - 60 years old; 2. American Society of Anesthesiologists (ASA) physical status rating I-II; 3. Supratentorial glioma (frontal, temporal, parietal, insular ；WHO grade I-III); 4. Native Chinese speaker; 5. Signed informed consent.
Exclusion criteria
1. Mallampati airway class≥III; 2. BMI\>30kg/m2; 3. Combined OSAS or Stop-BANG score≥3; 4. Hearing impairment 5. Combined epilepsy symptoms 6. Recurrent or multiple intracranial tumors 7. Concomitant other psychiatric or neurological disorders 8. Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The amplitude of auditory event-related potential | During the trial(up to 3 hours for each subject) | The amplitude of MMN and P300 |
| The latency of auditory event-related potential | During the trial(up to 3 hours for each subject) | The latency of MMN and P300 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain network functional connectivity | During the trial(up to 3 hours for each subject) | Using coherence ; phase slope index(PSI); phase locking value(PLV）;phase lag index(PLI）to evaluate the brain network functional connectivity of subjects |
Countries
China
Outcome results
None listed