Fatty Liver, Sleep Apnea, Obstructive
Conditions
Brief summary
Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively. Though studies show OSA may take part in the progression of hepatic steatosis, the independent contribution of OSA on liver fat accumulation is unknown. It is hypothesized that nocturnal intermittent hypoxia from OSA is the main driver of NAFLD in non-obese OSA patients. This study is to assess the effect of OSA on NAFLD in non-obese patients.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 18 years or more
Exclusion criteria
* underlying cause of liver disease * history of excessive alcoholic consumption (more than 30 g/day for men and 20 g/day for women) * secondary causes of hepatic steatosis (such as chronic use of systemic corticosteroids) * positive hepatitis B surface antigen, anti-hepatitis C virus antibody, or histological evidence of other concomitant chronic liver diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of subjects found to have fatty liver disease among obese patients with obstructive sleep apnea | baseline |
| Number of subjects found to have fatty liver disease among non-obese patients with obstructive sleep apnea | baseline |
Secondary
| Measure | Time frame |
|---|---|
| Number of subjects found to have fatty liver disease among obese subjects without obstructive sleep apnea | baseline |
| Number of subjects found to have fatty liver disease among non-obese subjects without obstructive sleep apnea | baseline |
| mesenteric fat thickness by ultrasound scan of all subjects | baseline |
Countries
Hong Kong
Contacts
Primary ContactKen KP Chan
Outcome results
None listed