Blood Sugar; High, Postprandial Hyperglycemia, Type2 Diabetes
Conditions
Brief summary
The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin \[IMD\], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial insulin in human subjects with relatively high fasting blood glucose, when consumed with a specific amount of digestible carbohydrate (rice porridge). The primary outcome of the study is the effect of fibers on postprandial blood glucose, whereas the secondary outcome will be its effect on postprandial blood insulin.
Interventions
OTHERControl
300 g rice porridge + 150 ml drinking water
OTHERIsomaltodextrin Low Dose
300 g rice porridge + (5 g IMD in 150 ml drinking water)
OTHERIsomaltodextrin High Dose
300 g rice porridge + (10 g IMD in 150 ml drinking water)
OTHERGPC partially digestible maltodextrin
300 g rice porridge + (15 g GPC fiber in 150 ml drinking water)
300 g rice porridge + (15 g RS4 starch in 150 ml drinking water)
Sponsors
Grain processing corporation
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
22 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (18.5 kg/m² ≤ BMI ≤ 29.9 kg/m²) * No history of abnormal glucose metabolism * No ongoing use of drugs affecting blood glucose levels * Fasting blood glucose between 90-110 mg/dL * Low dietary fiber intake (less than 15 g per day)
Exclusion criteria
* Diabetic individuals * Individuals with history of gastrointestinal disease * Pregnant or nursing women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial glycemic response | Acute study: [3 hours of measurement after consumption of test food] | Blood glucose will be measured, (AUC) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial insulin response | Acute study: [3 hours of measurement after consumption of test food] | Blood insulin will be measured, (AUC) |
Countries
United States
Outcome results
None listed