Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars

Effect of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps: A Randomized Clinical Trial

Status

UNKNOWN

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05348824

Enrollment

Registered

2022-04-27

Start date

2022-08-31

Completion date

2023-04-30

Last updated

2022-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotic Pulp

Brief summary

The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using Moringa oleifera leaf extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit

Interventions

DIETARY_SUPPLEMENTMoringa oleifera leaf

Leaf extract preparation

DRUGSodium hypochlorite

2.5% sodium hypochlorite (household bleaching agent)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

1. Systematically healthy patient (ASA I,II). 2. Age between 20 and 55 years 3. Male or female. 4. Asymptomatic mandibular premolar teeth diagnosed with pulp necrosis with apical periodontitis. 5. Radiographic examination using Digora intraoral periapical sensor plate and software (Digora; Soredex, Helsinki, Finland) showing mandibular premolars with (smaller than 3 mm (0-2 mm)) periapical radiolucency.

Exclusion criteria

1. Medically compromised patients having significant systemic disorders. (ASA III or IV). 2. History of intolerance to NSAIDS. 3. Teeth with: * Immature roots * Vital pulp tissues. * Association with swelling. * Acute peri-apical abscess or acute exacerbation of a chronic abscess. * Mobility Grade II or III. * Previously accessed or endodontically treated * Deep periodontal pockets more than 4 mm * Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions. 4. Patients who could not interpret the NRS. 5. Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative pain	up to 48 hours postoperatively	postoperative pain will be marked by the patient using the Numerical rating scale (NRS) chart which is an 11 point scale consisting of numbers from 0 through 10, where: 0: reading represents no pain 1-3: readings represent mild pain 4-6: readings represent moderate pain 7-10: readings represent severe pain

Secondary

Measure	Time frame	Description
Intracanal bacterial load change	First sample is taken at Time 0 T0 then second sample taken after chemo-mechanical preparation on 15 minutes at Time 1 T1.	The intracanal bacterial load change will be determined using agar culture technique by counting the colony forming units per milliliter (CFUs/mL) before and after root canal preparation.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026