Healthy
Conditions
Keywords
Fetal thymus volume, In vitro fertilization
Brief summary
The purpose of the study was to compare the fetal thymus volumes of 18-24-week pregnant women with In Vitro Fertilization (IVF) and spontaneous pregnant women.
Interventions
None listed
Sponsors
Karadeniz Technical University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 34 Years
Healthy volunteers
Yes
Inclusion criteria
* pregnant between 18-24 weeks * had no complaints * between the ages of 18-35 * conceived with in vitro fertilization or spontaneously
Exclusion criteria
* history of endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), systemic diseases (e.g. asthma), collagen disorder, hypercholesterolemia, sickle cell anemia, or neoplasm, * those who had a history of coronary artery disease, angina, or myocardial infarction, or a history of hypertension, coronary arteritis, and electrocardiographic changes that suggest any known history of vascular, infectious, or inflammatory disease, maternal autoimmune disease, * use of any drugs other than those used for IVF (e.g. insulin sensitizing drugs, oral contraceptives, antiandrogens, statins, aspirin, and corticosteroids) in the 3 months before the pregnancy, * multiple pregnancy, * present cigarette and alcohol use, * abnormal renal, hepatic, and thyroid function test results; * refusing to participate in the study, * abnormal fetal findings (fetal anomaly, increased nape transparency, first-second trimester screening test disorder), * cases who did not meet the criteria for pregnancy after the first tube treatment (ICSI-ET) because of normoresponder, unexplained infertility, or male factor
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measurement of fetal thymus volume | 18-24 week pregnant women | The thymus is located at the superior part of the fetal rib cage. When the transverse section, which includes three vessel images (Superior Vena Cava, Aorta, Pulmonary Artery) is taken, fetal sternum is observed between the three-vessel view and fetal lungs. It is found as a hypoechoic two-lobe structure in the anterior mediastinum compared to other tissues. The fetal thymus dimensions were evaluated by one single person by using the VOLUSON E-10 ultrasonography, which can make VOCAL measurements with 2D and 3D VOCAL Program in 3-vessel trachea sections. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| frequency of pregnancy complications | during pregnancy and at delivery week | The cases were followed up during pregnancy and at delivery week, and frequency of preeclampsia, non-reliable fetal status, Intrauterine growth restriction and neonatal intensive care requirement wererecorded. |
Countries
Turkey (Türkiye)
Outcome results
None listed