Exercise Induced Muscle Damage
Conditions
Brief summary
Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg & 1500mg has been shown to be effective. Curcumin supplementation has been ingested in numerous different ways however, no previous research to date has used curcumin in a hydrolysed (drinkable) format. The aim of this study is to investigate whether hydrolysed curcumin can reduce indices of muscle damage and improve recovery, whilst also examining a potential dose-response effect.
Interventions
DIETARY_SUPPLEMENTCurcumin
Curcumin Supplementation
Sponsors
St Mary's University College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria are as follows: * between the age of 18-35 * non-smoker * no previous history of cardiovascular, respiratory, or neurological problems * not taking anticoagulant medication * injury-free in the 3 months prior to scheduled participation in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood markers | Baseline | Blood samples will be taken for analysis of markers of IL-6, IL-1β, TNF-α, IL-1, IL-4, IL-10 and CK will be taken |
| Ford and Fort | Baseline | Capillary sample Ford and Fort tests |
| Soreness | Baseline | Perceived muscle soreness scale - Visual analouge scale |
| Muscle Structure | Baseline | Muscle swelling - thigh girth + Ultrasound measurement |
| Muscle Function | Baseline | maximal strength |
Contacts
Primary ContactLuke Hughes, PhD
Backup ContactIan Grant, MSc
Outcome results
None listed