Gastric Intestinal Metaplasia, Magnifying Endoscopy, Narrow-band Imaging
Conditions
Brief summary
Long-term Helicobacter pylori infection causes premalignant gastric conditions, such as atrophic gastritis and intestinal metaplasia. Image-enhanced endoscopy techniques such as narrow-band imaging (NBI) and magnifying endoscopy improve the diagnosis of gastric intestinal metaplasia (GIM). However, there are no comparative data on the utility of NBI and magnifying endoscopy for diagnosing GIM.
Detailed description
This study aims to evaluate the diagnostic performance of NBI and magnifying endoscopy for GIM in a country with high risk of gastric premalignant lesions.
Interventions
PROCEDURENarrow-band imaging endoscopy
During endoscopy, gastric mucosal patterns would be examined by magnifying narrow-band imaging.
Sponsors
Soonchunhyang University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Inclusion criteria
* Gastroscopy can be performed * Pathological analysis can be performed for analysis of gastric atrophy and intestinal metaplasia
Exclusion criteria
* Age \< 20 or \> 80 years * Anemia (serum hemoglobin level \< 10 g/dL) * Severe systemic disease * Advanced chronic liver disease * Use of certain medications, including proton pump inhibitors, H2-receptor antagonists, or antibiotics * History of H. pylori eradication * History of gastric surgery * Recent history of upper gastrointestinal bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastric intestinal metaplasia | 4 weeks | Gastric intestinal metaplasia would be assessed using pathological examination. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Degree of chronic gastritis | 4 weeks | Gastric atrophy would be evaluated on the basis of histopathological examination (updated Sydney system). |
Countries
South Korea
Outcome results
None listed