SLMAP and EPO Genetic Polymorphism in Diabetic Retinopathy

Evaluation of the Relationship Between SLMAP and EPO Genetic Polymorphism and the Risk of Diabetic Retinopathy in Egyptian Diabetic Patients: A Case-Control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05344690

Enrollment

180

Registered

2022-04-25

Start date

2022-05-20

Completion date

2023-06-30

Last updated

2024-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Retinopathy

Brief summary

A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.

Detailed description

Traditional environmental risk factors, such as glycemic control and duration of diabetes, failed to fully explain why some individuals remain protected while others progress to severe diabetic retinopathy. Several studies suggest variations in diabetic retinopathy prevalence depending on racial background and genetic polymorphism.

Interventions

GENETICSLMAP and EPO genetic polymorphism

Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Age \>30-60 * Type 2 DM * Duration of diabetes from 5-10 years * Egyptian patients

Exclusion criteria

* Other ophthalmic diseases not related to diabetes

Design outcomes

Primary

Measure	Time frame	Description
Association of SLMAP gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis	At baseline (upon confirmed diagnosis of diabetic retinopathy)	the odds ratio of being diagnosed with diabetic retinopathy in those with SLMAP rs17058639 single nucleotide polymorphism compared to wild type
Association of EPO gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis	At baseline (upon confirmed diagnosis of diabetic retinopathy)	The odds ratio of being diagnosed with diabetic retinopathy in those with EPO rs551238 single nucleotide polymorphism compared to wild type

Secondary

Measure	Time frame	Description
The association of confounding factors on the incidence of diabetic retinopathy	At baseline	A multiple logistic regression model will be fitted to assess the association of diabetic retinopathy to confounders (microalbuminuria, lipid profile, age, gender,...etc.)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026