Cardiovascular Diseases, Diet, Healthy, Hypertension
Conditions
Keywords
health disparity, endothelial function, hypertension, vegan diet, Black Americans, inflammation
Brief summary
The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.
Interventions
OTHERTypical American Diet
Participants self-reported adherence to a typical American diet prior to enrolling in the study. This factor determined cross-sectional group allocation.
OTHERPlant-Based Diet
Participants self-reported adherence to a 100% plant-based diet prior to enrolling in the study. This factor determined cross-sectional group allocation.
Sponsors
The University of Texas at Arlington
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Self-identify as African American/Black * Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet * Age 18-40
Exclusion criteria
* History of smoking within 2 years or being a current smoker * Taking vasoactive medications * Having overt cardiovascular, metabolic, or neurological disease * Pregnant individuals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG) | Day 1 |
| C-reactive protein | Day 1 |
| Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline) | Day 1 |
| Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline) | Day 1 |
| Pulse wave velocity (carotid-to-femoral) | Day 1 |
| Augmentation index (AIx@HR75) | Day 1 |
| Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline) | Day 2 |
| Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline) | Day 2 |
| Peripheral blood pressure (systolic, diastolic, mean) | Day 1 |
| Central blood pressure (systolic, diastolic, mean) | Day 1 |
Countries
United States
Outcome results
None listed