Atrial Fibrillation
Conditions
Brief summary
Remote ischemic preconditioning is one way to influence the success of therapy in cardiovascular patients. By means of remote ischemic preconditioning the incidence of atrial fibrillation after cardiac surgery was reduced by 54%. The investigators aim to investigate the effect of ischemic preconditioning in an easy-to-perform protocol with regard to the recurrence of atrial fibrillation after electrical cardioversion.
Interventions
PROCEDURERemote ischemic preconditioning
Remote ischemic preconditioning through inflation of a blood pressure cuff to pressure values \> 200mmHg for 5 minutes followed by 5 minutes of reperfusion (3 times each) before electrocardioversion Electrical cardioversion for atrial fibrillation (100, 150, 200 Joule)
PROCEDURESham preconditioning
Inflation of a blood pressure cuff to pressure values \ 10mmHg for 5 minutes followed by 5 minutes of reperfusion (3 times each) before electrocardioversion
Sponsors
St. Josefs-Hospital Wiesbaden GmbH
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patients with paroxysmal or persistent atrial fibrillation who give written informed consent to participate in the study * Age \> 18 years * Consent capacity
Exclusion criteria
* Age under 18 years * Pregnancy * Lack of consent capacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of subjects with recurrence of atrial fibrillation 30 days after electrical cardioversion | 30 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with short-term cardioversion success | 30 seconds | Sinus rhythm lasting \> 30 seconds after electrocardioversion |
| Minimum energy required for successful electrocardioversion (in Joule) | 30 days | — |
| Cumulative energy applied for successfull electrocardioversion (in Joule) | 30 days | — |
| Cumulative number of shocks delivered for successfull electrocardioversion | 30 days | — |
| Number of patients experiencing death from any cause, stroke /transient ischemic attack, relevant post-ECV arrhythmia and procedure-associated complications | 30 days | Safety endpoint |
Countries
Germany
Outcome results
None listed