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Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05341258
Enrollment
50
Registered
2022-04-22
Start date
2022-01-01
Completion date
2022-08-01
Last updated
2022-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Copd, Critical Illness, Pulmonary Embolism, Shock, Trauma, Ventilation Perfusion Mismatch

Brief summary

Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

Interventions

DIAGNOSTIC_TESTEtCO2

EtCO2

DIAGNOSTIC_TESTPaCO2

PaCO2

Sponsors

Gaziosmanpasa Research and Education Hospital
Lead SponsorOTHER_GOV

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Critical Care Patients intubated in last 24 hours.

Exclusion criteria

* Patients younger than 18 years old.

Design outcomes

Primary

MeasureTime frameDescription
Mortality6 monthsEvaluation of correlation between PaCO2 and ETCO2 gradient difference and mortality in intubated critical care patients and mortality rates

Secondary

MeasureTime frameDescription
ICU Length of Stay6 monthsDays patients treated at ICU
Ventilator Free Days6 monthsDays during which the patient was mechanically ventilated

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026