Chronic Thromboembolic Pulmonary Hypertension
Conditions
Keywords
Pulmonary hypertension;, chronic thromboembolic pulmonary hypertension, pulmonary embolism, proteomic pattern
Brief summary
Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).
Detailed description
However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH). This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).
Interventions
BIOLOGICALblood sample
to realize proteomic analysis.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations) * Patients who require a right heart catheterization. * Patient affiliated or entitled to a social security plan * Patient having received informed information about the study informed about the study
Exclusion criteria
* Patient with a normal perfusion lung scan * Person under legal guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH) | Day: 0 | Analysis of the final diagnosis retained for the patient : Chronic thromboembolic pulmonary hypertension (CTEPH) (population of interest), pre-capillary Pulmonary Hypertension (PH) other than Chronic thromboembolic pulmonary hypertension (CTEPH), post-capillary Pulmonary Hypertension (PH), no Pulmonary Hypertension (PH). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of recording of hemodynamic data at diagnosis | Day: 0 | hemodynamic data : pulmonary vascular resistance, cardiac index, pulmonary arterial pressures |
| Analysis of recording of hemodynamic after 6 months of treatment | 6 months | hemodynamic data : pulmonary vascular resistance, |
| Analysis of recording of hemodynamic data at diagnosis and at death | 6 months | hemodynamic data : pulmonary arterial pressures |
Countries
France
Contacts
Primary ContactLaurent BERTOLETTI, MD PhD
Backup ContactCarine LABRUYERE
Outcome results
None listed