Myocardial Infarction
Conditions
Keywords
physical activity, Accelerometer, Registry
Brief summary
The association between objectively measured physical activity intensities (light, moderate and vigorous), sedentary time and clinical outcomes has not been clarified in patients after a myocardial infarction. The overall objective of the study is to explore associations between accelerometer measured physical activity and clinical outcomes after a myocardial infarction. Moreover, the association between changes in physical activity and outcomes will be assessed.
Detailed description
It is estimated to include 4000 patients with myocardial infarction during 2 years. Patients will wear the accelerometer for 7 days at follow-up visits (2 months and 1 year) after discharge. The investigators will examine the dose-response relations of several exposure variables from the accelerometer measurements with the outcomes.
Interventions
OTHERAccelerometer measurement
Study personnel will initiate an accelerometer and inform the patient to wear the accelerometer with an elastic belt on their right hip during waking hours for seven consecutive days. Moreover, patients are instructed to register their wear time in an activity diary in paper form. In addition, patients will register their working hours, if relevant. After seven days, patients send back the accelerometer and diary in a pre-paid envelope. The same procedure is repeated at the second follow-up visit at 1 year.
Sponsors
Sahlgrenska University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Signed informed consent * Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART * Age 18-79 years at discharge from hospital * Attending the first visit in the cardiac rehabilitation (CR) registry SEPHIA (2 months after discharge)
Exclusion criteria
* Inability to understand Swedish * Non-ambulatory * Any mental condition that may interfere with the possibility for the patient to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiovascular event (MACE) | 1 year after the index cardiac event | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Non-fatal myocardial infarction | 1 year after the index cardiac event | Incidence of non-fatal myocardial infarction |
| Non-fatal ischemic stroke | 1 year after the index cardiac event | Incidence of non-fatal ischemic stroke |
| Coronary revascularization | 1 year after the index cardiac event | Incidence of coronary revascularization |
| Cardiovascular mortality | 1 year after the index cardiac event | Incidence of cardiovascular mortality |
| Major adverse cardiovascular event (MACE) | 3 years after the index cardiac event | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure |
| All-cause death | 1 year after the index cardiac event | Incidence of all-cause death |
| Heart failure | 1 year after the index cardiac event | Incidence of hospitalization for new or worsening heart failure |
Other
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 1 year after the index cardiac event | mmHg |
| Smoking status | 1 year after the index cardiac event | 0=Never smoker, 1=Former smoker \> 1 month, 2=Smoker |
| Waist circumference | 1 year after the index cardiac event | cm |
| Body weight | 1 year after the index cardiac event | kg |
| The Swedish Healthy diet questionnaire | 1 year after the index cardiac event | Four questions with Likert scale 0-3 points. Higher scores indicate better outcomes |
| Health-related quality of life (EuroQol- 5 Dimension) | 1 year after the index cardiac event | EuroQol- 5 Dimension (EQ-5D-3L) The EQ-5D-3L comprises the following five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 3 levels: no problems, some problems, and extreme problems. Higher scores indicate better outcomes. |
| Health-related quality of life (EQ visual analogue scale) | 1 year after the index cardiac event | EQ visual analogue scale (EQ VAS). The EQ VAS records the respondent's self-rated health on a vertical, visual analogue scale where the endpoints are labelled 'Best imaginable health state' and 'Worst imaginable health state'. |
| Triglycerides | 1 year after the index cardiac event | Plasma levels of triglycerides (mmol/L). Higher values indicate worse outcome. |
| High-density lipoprotein (HDL) cholesterol | 1 year after the index cardiac event | Plasma levels of HDL (mmol/L). Higher values indicate better outcome |
| Low-density lipoprotein (LDL) cholesterol | 1 year after the index cardiac event | Plasma levels of LDL cholesterol (mmol/L). Higher values indicate worse outcome |
| Hemoglobin A1c (HbA1c) | 1 year after the index cardiac event | HbA1c (mmol/L). Measures the amount of blood sugar. Higher values indicate worse outcome |
Countries
Sweden
Contacts
Primary ContactMaria Bäck, PhD
Backup ContactJohanna Lilliecrona, MSc
Outcome results
None listed