Atherosclerosis, Cardiovascular Diseases, COPD, Lung Function Decreased
Conditions
Keywords
Low and middle income countries, Non-communicable diseases, Latin America, Cardio-respiratory disease
Brief summary
Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them. The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance. The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained. A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.
Interventions
GENETICGenetic risk variants
Exposure: Genetic predisposition to complex diseases.
OTHERDiet
Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.
BEHAVIORALPhysical activity
Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.
OTHERSocio-economic conditions
Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).
Sponsors
The Administrative Department of Science, Technology and Innovation, Colciencias
National Center for Research in Chronic Diseases, Colombia
Johns Hopkins Bloomberg School of Public Health
Universidad Catolica de Cordoba
University of Chile
Universidad de Sucre
Universidad del Magdalena
Universidad de Cartagena
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults * Native from Colombian Caribbean Coast
Exclusion criteria
* Pregnant women * Walking physical disability * Cognitive disability * Patients under treatment for any type of cancer * Clinical record of primary chronic endocrine disease * Clinical record of major respiratory tract surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic syndrome | baseline - 10 years (end of follow up) | Pathologic findings for blood pressure, triglycerides, HDLc, serum glucose, and/or enlarged waist circumference (three or more of this criteria found simultaneously) |
| Atherosclerosis | baseline - 10 years (end of follow up) | Carotid atheroma identified by eco-doppler imaging test |
| Acute cardiovascular event | 2nd year (first follow up) - 10 years (end of follow up) | Record of acute coronary heart disease, miocardipathy, and ischemic or hemorragic cerebrovascular event. |
| Chronic airflow obstruction | baseline - 10 years (end of follow up) | Obstruction patterns in post-bronchodilator spirometry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Chronic Obstructive Pulmonary Disease (COPD) | baseline - 10 years (end of follow up) | Diagnosis of by lung function test (post-bronchodilator spirometry) and/or clinical criteria |
| Hypertension | baseline - 10 years (end of follow up) | Primary high blood pressure according to clinical criteria |
| Type 2 Diabetes Mellitus | baseline - 10 years (end of follow up) | Abnormal results in fasting serum glucose test and/or HbA1c test. |
| Dyslipidemia | baseline - 10 years (end of follow up) | High serum cholesterol, triglycerides or LDLc; and/or low HDLc |
Countries
Colombia
Outcome results
None listed