Cirrhosis, Liver, Splenectomy; Status
Conditions
Keywords
Cirrhosis, Splenectomy, Laparoscopy, Immune function, Azygoportal disconnection
Brief summary
In this study, the investigators compared the improvement of immune function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative immune function and improve patient prognosis.
Detailed description
The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy and azygoportal disconnection, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the immune function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including the counts of leukocytes, neutrophils, lymphocytes, and monocytes, and the levels of CD4+,CD8+,CD4+/CD8+, and CD19,CD20.
Interventions
Laparoscopic splenectomy and azygoportal disconnection is performed by the same surgical team.
Sponsors
Northern Jiangsu People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism * gastroesophageal variceal bleeding * Informed consent to participate in the study
Exclusion criteria
* Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Human immunodeficiency virus (HIV) infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The immune function CD4+ at 3 months after surgery | 3 months | The level of the immune function CD4+ at 3 months after surgery |
| The immune function CD4+ at 6 months after surgery | 6 months | The level of the immune function CD4+ at 6 months after surgery |
| The immune function CD4+ at 12 months after surgery | 12 months | The level of the immune function CD4+ at 12 months after surgery |
| The immune function CD4+ at 24 months after surgery | 24 months | The level of the immune function CD4+ at 24 months after surgery |
| The immune function CD8+ at 3 months after surgery | 3 months | The level of the immune function CD8+ at 3 months after surgery |
| The immune function CD8+ at 6 months after surgery | 6 months | The level of the immune function CD8+ at 6 months after surgery |
| The immune function CD8+ at 12 months after surgery | 12 months | The level of the immune function CD8+ at 12 months after surgery |
| The immune function CD8+ at 24 months after surgery | 24 months | The level of the immune function CD8+ at 24 months after surgery |
| The immune function CD4+/CD8+ at 3 months after surgery | 3 months | The level of the immune function CD4+/CD8+ at 3 months after surgery |
| The immune function CD4+/CD8+ at 6 months after surgery | 6 months | The level of the immune function CD4+/CD8+ at 6 months after surgery |
| The immune function CD4+/CD8+ at 12 months after surgery | 12 months | The level of the immune function CD4+/CD8+ at 12 months after surgery |
| The immune function CD4+/CD8+ at 24 months after surgery | 24 months | The level of the immune function CD4+/CD8+ at 24 months after surgery |
| The immune function CD19 at 3 months after surgery | 3 months | The level of the immune function CD19 at 3 months after surgery |
| The immune function CD19 at 6 months after surgery | 6 months | The level of the immune function CD19 at 6 months after surgery |
| The immune function CD19 at 12 months after surgery | 12 months | The level of the immune function CD19 at 12 months after surgery |
| The immune function CD19 at 24 months after surgery | 24 months | The level of the immune function CD19 at 24 months after surgery |
| The immune function CD20 at 3 months after surgery | 3 months | The level of the immune function CD20 at 3 months after surgery |
| The immune function CD20 at 6 months after surgery | 6 months | The level of the immune function CD20 at 6 months after surgery |
| The immune function CD20 at 12 months after surgery | 12 months | The level of the immune function CD20 at 12 months after surgery |
| The immune function CD20 at 24 months after surgery | 24 months | The level of the immune function CD20 at 24 months after surgery |
Countries
China
Contacts
Primary ContactGuo-Qing Jiang, MD
Backup ContactDou-Sheng Bai, MD
Outcome results
None listed