Knee Osteoarthritis
Conditions
Brief summary
The purpose of this study is to determine the intra-articular and serum levels of vancomycin over the first 24 hours postoperatively after intra-articular administration of a standard dose of vancomycin in primary total knee arthroplasty.
Interventions
After closure of the arthrotomy, 1 g of vancomycin powder suspended in 30ml of normal saline was injected directly into the joint with an 18-gauge needle.
Sponsors
The Affiliated Hospital of Qingdao University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 50 and 80 2. Total knee arthroplasty for primary osteoarthritis. Primary diagnosis of knee osteoarthritis
Exclusion criteria
1. Diminished mental capacity 2. Vancomycin allergy 3. Chronic kidney disease stage III and stage IV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intra-articular vancomycin concentration | 2 hours, 8 hours and 24 hours postoperatively | — |
| Serum vancomycin concentration | 2 hours, 8 hours and 24 hours postoperatively | — |
| Renal function | Postoperative Day 1 and Day 3 | blood urea nitrogen (BUN), creatinine (Cr), GFR |
| Blood loss | Postoperative Day 3 | — |
Countries
China
Outcome results
None listed