Dietary Supplement, Placebo
Conditions
Keywords
dietary supplements, nitrate, neuromuscular function
Brief summary
Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments). However, the effects of beetroot juice ingestion on neuromuscular performance in women older adults are barely studied. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance in women older adults
Detailed description
Beetroot juice supplementation has shown the capacity for provoking different physiological effects that could affect human performance (e.g. vasodilation and muscle contraction increments). Although this dietary supplement has been commonly used for improving sports performance in recreational or professional athletes, the scientific literature in older adults is scarce. Thus, in our knowledge, no previous studies have analyzed the side effects associated to ingestion in this population group. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance and side effects associated with ingestion in women older adults.
Interventions
DIETARY_SUPPLEMENTbeetroot juice
Acute effects of beetroot juice or placebo juice ingestion
Sponsors
Universidad Francisco de Vitoria
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
65 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Women \>65 or \<85 years of age. * In good health, as determined by the investigator's review of history.
Exclusion criteria
(based in previous studies on this topic (doi: 10.1093/gerona/glaa311). Men and women \<65 or \>85 years of age Unable to provide informed consent Current smokers Significant orthopedic limitations or other contraindications to strenuous exercise Those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy Those taking anti-coagulants or on anti-platelet therapy History of neuromuscular disease (e.g., cervical spondylotic radiculomyelpathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies) Cardiovascular disease (e.g., \> stage I hypertension, heart failure, myocardial infarction/ischemia significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), Moderate or severe valvular disease, renal disease, liver disease, or anemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in 6-m gait speed test | 1-week | Using a photocell timing gates (seconds) |
| Changes in Sit and Stand Test | 1-week | Using Power Frail APP |
| 6-Minute Walk Test | 1-week | — |
| Changes in maximal isometric handgrip strength (N) | 1-week | Using a dynamometer and measuring dominant/ non-dominant side |
| Changes in Time Up and Go test | 1-week | Using a photocell timing gates (seconds) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Side effects questionnarie | 1-week | Using a side-effects questionnarie (YES/NO scale) |
| Rate of perception effort (RPE) | 1-week | Using a validated scale (1-10 points) |
Countries
Spain
Outcome results
None listed