Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.

Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients..

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05337059

Acronym

PULMOESO

Enrollment

Registered

2022-04-20

Start date

2022-03-30

Completion date

2026-04-01

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, Human

Brief summary

Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based on both expiratory and inspiratory transpulmonary pressures.

Detailed description

Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. A positive expiratory transpulmonary pressure may be considered as a target to limt the risk of collapse in dependant lung regions. Some authors propose to titrate PEEP to target an inspiratory transpulmonary pressure of 20cmH20 to limit the risk of overdistension in non-dependant regions.The aim of this study is to assess the feasibility and the physiological effects of a new method based on both expiratory and inspiratory transpulmonary pressures.

Interventions

OTHERPEEP and Tidal Volume Titration

PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

feasibility, monocentric, prospective study

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years or older * Moderate to severe ARDS * Written informed consent obtained from patient' surrogates

Exclusion criteria

* Pneumothorax * Known pregnancy * Contraindication to electrical impedance tomography or esophageal pressure measurements

Design outcomes

Primary

Measure	Time frame	Description
Ventilation strategy failure	48 hours	Number of patients with failure criteria (barotrauma, hemodynamic failure, rescue therapy or acidemia)

Secondary

Measure	Time frame	Description
Short term physiologicals effects on hemodynamics	45 minutes	Cardiac index assed by Echocardiography (L/min/m\^2)
All-cause mortality at day 28	28 days	All-cause mortality
Ventilator-free days at day 28	28 days	Number of alive ventilator free days
Short term physiologicals effects on respiratory mechanics	45 minutes	recruited lung volume (mL)
Short term physiologicals effects on gas exchange	45 minutes	PaO2/FiO2 ratio (mmHg)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 15, 2026