Coagulation Profile in Patients Undergoing Coronary Angiography and Percutaneous Coronary Intervention

Coagulation Profile in Patients Undergoing Coronary Intervention Measured With Activated Clotting Time, Global Thrombosis Test and Platelet Inhibition VerifyNow P2Y12 Test

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05336669

Acronym

GlobalACT

Enrollment

Registered

2022-04-20

Start date

2022-04-30

Completion date

2023-08-31

Last updated

2022-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Coronary Insufficiency, Smoking

Keywords

coronary angiography, activated clotting time, platelet inhibition

Brief summary

The activated clotting time (ACT), global thrombosis test (GTT-3), platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI).

Detailed description

The activated clotting time (ACT), global thrombosis test (GTT-3) and platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI) - 20 smoking and 20 non-smoking.The measurements will take place: before coronary angiography (CA), 10 minutes after unfractionated heparin (HNF), 2h after CA, 6h after CA, 30 days after CA

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* patients scheduled do CA \>18 years old

Exclusion criteria

* pregnancy * previous treatment with P2Y12 inhibitors, novel oral anticoagulants (NOAC) or warfarin acenocoumarol in last 24 hours

Design outcomes

Primary

Measure	Time frame	Description
ACT change	Baseline ACT , 10 minutes ACT, 2 hours ACT, 6 hours ACT, 30 days ACT	Activated Clotting Time
GTT-3 change	Baseline GTT-3, 10 minutes GTT-3, 2 hours GTT-3, 6 hours GTT-3, 30 days ACT	Global Thrombosis Test
VerifyNow change	Baseline VerifyNow, 10 minutes VerifyNow, 2 hours VerifyNow, 6 hours VerifyNow, 30 days ACT	Platelet inhibition P2Y12 test

Contacts

Primary ContactBogumił Ramotowski, MD, PhD

bram@onet.pl+48604355784

Outcome results