Intellectual Disability
Conditions
Keywords
Intellectual disability, Physical activity, Cardiovascular fitness, Bone health, Body composition
Brief summary
Currently, there is a paucity of quality research within the field of health science with a focus on persons with intellectual disabilities, and especially how longer lasting periods of varied physical activity affects the target group. There is a lack of insight, in how persons with intellectual disabilities learns and retains movement skills. Thus, the research group behind this project will investigate the following research questions: 1. Does 40 weeks of intense and varied sports and physical activities as an intervention lead to positive changes in health status for adults with intellectual disabilities? 2. Can lasting effects be measured three and six months after the intervention? 3. Does the intervention improve the motor competences for the participants? 4. How does defined groups of adult persons with Down syndrome and Cerebral Palsy learn and retain a new motor skill?
Interventions
OTHERPhysical activity
2 hours of physical activity per day, 5 days per week, for the intervention period
Sponsors
Novo Nordisk A/S
Elsass Foundation
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A physically active intervention group is compared to a physically inactive control group
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Presence of an intellectual disability
Exclusion criteria
* Participants under guardianship * Unable to give informed consent to participate on their own
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in body weight | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Body weight in kilograms |
| Change in body fat mass | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Body fat mass in kilograms |
| Change in lean mass | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Lean body mass in kilograms |
| Change in fat free mass | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Fat free mass in kilograms |
| Change in cardiovascular fitness | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Change in heart rate during the same absolute submaximal exercise intensity |
| Change in areal bone mineral density of the whole body | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Areal bone mineral density in grams per square centimeter (g/cm2) of the whole body |
| Change in T-scores of the whole body | Measurements will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Whole body T-score. An arbitrary measure, describing the bone mineral density of the subjects relative to a reference value from 30 year old healthy persons. |
| Change in areal bone mineral density of the lumbar spine (L1-L4) | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Areal bone mineral density in grams per square centimeter (g/cm2) of the lumbar spine (L1-L4) |
| Change in T-scores of the lumbar spine (L1-L4) | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Lumbar spine (L1-L4) T-score. An arbitrary measure, describing the bone mineral density of the subjects relative to a reference value from 30 year old healthy persons. |
| Change in areal bone mineral density of the bilateral femur regions | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Areal bone mineral density grams per square centimeter (g/cm2) of the bilateral femur regions |
| Change in T-scores of the bilateral femur regions | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | T-scores of the bilateral femur regions. An arbitrary measure, describing the bone mineral density of the subjects relative to a reference value from 30 year old healthy persons. |
| Change in plasma bone turn-over marker (CTX) | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Carboxy-terminal collagen crosslinks (CTX), measured as μg/L |
| Change in Plasma bone turn-over marker (P1NP) | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Procollagen type 1 N-terminal propeptide (P1NP), measured as μg/L |
| Plasma bone turn-over marker (Osteocalcin) | Measurement will be obtained at pre-intervention, (0 weeks), mid intervention (14 weeks) and post intervention (40 weeks) | Osteocalcin, measured as μg/L |
Countries
Denmark
Outcome results
None listed