Clinical Comparison of Topical Application of Alvogyl Versus Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing

Clinical Comparison of Topical Application of Alvogyl Versus Topical Application of Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing : A Randomized Controlled Clinical Trial

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05334745

Enrollment

Registered

2022-04-19

Start date

2021-12-01

Completion date

2023-01-01

Last updated

2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound Healing

Brief summary

The aim of the study is to evaluate the effect of application of Alvogyl versus hyaluronic acid in decreasing postoperative pain and promoting healing in the palatal wound following the free gingival graft procedure

Detailed description

Postoperative pain and bleeding are the most common complications after palatal graft harvesting, also postsurgical swelling have been reported. Although hemostatic agents, mechanical barriers, bioactive materials, antibacterial and antiseptic agents and herbal products have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction have been reported . No gold standard has been identified, thus there is a need for further investigations aiming to reach the best possible treatment modality for pain relief and prevention of reported complications following harvesting of palatal graft .

Interventions

OTHERAlvogyl

application of Alvogyl in the palatal wound with stent versus hyaluronic acid application

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with mucogingival defects scheduled for free gingival graft * Age from 18 years up to 60 * Medically healthy patient

Exclusion criteria

* Systemic diseases that may be a contraindication for any surgeries. * Loss of maxillary premolars and molars. * Pregnancy or lactation * Smoking

Design outcomes

Primary

Measure	Time frame	Description
postoperative pain	7th days	Pain through one week using the visual analogue scale (VAS)

Secondary

Measure	Time frame	Description
Wound healing	7th, 14th, 21st and 30th days.	* Wound healing index through one month . * The healing index has 5 grades which are 5(excellent healing), 4(very good healing), 3 (good healing), 2(poor healing) and 1(very poor healing)

Countries

Egypt

Contacts

Primary Contactmohy eldin aboelazayem, TA

mohy.aboelazayem@dentistry.cu.edu.eg+201005007001

Backup Contactshaimaa Nasr, PHD

dr.shaimaanasr@gmail.com+01272789994

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026