Genetic Hypertension, Genetic Predisposition
Conditions
Brief summary
This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.
Detailed description
A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.
Interventions
OTHERFamily history of hypertension
Presence or absence of a family history of hypertension in a cross sectional study design.
Sponsors
Montclair State University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 32 Years
Healthy volunteers
Yes
Inclusion criteria
* Generally healthy
Exclusion criteria
* Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left Ventricular Mass | Day 2 | Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound. |
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Positive Family History of Hypertension Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension.
Family history of hypertension: Presence or absence of a family history of hypertension in a cross sectional study design. | 29 |
| Negative Family History of Hypertension Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. | 32 |
| Total | 61 |
Baseline characteristics
| Characteristic | Positive Family History of Hypertension | Negative Family History of Hypertension | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 29 Participants | 32 Participants | 61 Participants |
| Age, Continuous | 23.44827586 years STANDARD_DEVIATION 2.384266987 | 22.6875 years STANDARD_DEVIATION 2.966887149 | 23.04918033 years STANDARD_DEVIATION 2.7106 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 4 Participants | 8 Participants | 12 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 25 Participants | 24 Participants | 49 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants |
| Left Ventricular Mass/Body Surface Area | 88.35017813 grams/meter squared STANDARD_DEVIATION 17.30587475 | 73.51184729 grams/meter squared STANDARD_DEVIATION 17.74896472 | 80.56613572 grams/meter squared STANDARD_DEVIATION 18.9302 |
| Region of Enrollment United States | 29 Participants | 32 Participants | 61 Participants |
| Sex: Female, Male Female | 18 Participants | 19 Participants | 37 Participants |
| Sex: Female, Male Male | 11 Participants | 13 Participants | 24 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 29 | 0 / 32 |
| other Total, other adverse events | 0 / 29 | 0 / 32 |
| serious Total, serious adverse events | 0 / 29 | 0 / 32 |
Outcome results
Primary
Left Ventricular Mass
Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound.
Time frame: Day 2
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Positive Family History of Hypertension | Left Ventricular Mass | 155.1680523 gram | Standard Deviation 42.6141251 |
| Negative Family History of Hypertension | Left Ventricular Mass | 129.5013331 gram | Standard Deviation 41.76454204 |