Cardiac T1 Mapping Enables Risk Prediction of LV Dysfunction After Surgery for Aortic Regurgitation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05332184

Enrollment

Registered

2022-04-18

Start date

2016-07-01

Completion date

2020-03-13

Last updated

2022-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Regurgitation

Brief summary

To assess whether cardiac T1 mapping for detection of myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.

Detailed description

We hypothesized that a diffuse interstitial myocardial fibrosis may be present in AR patients who experience early systolic LV dysfunction after aortic valve surgery. We aimed to evaluate the association between preoperative cardiac T1 mapping for detection of myocardial fibrosis and early systolic LV dysfunction after surgery for aortic regurgitation.

Interventions

PROCEDUREaortic valve surgery

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Consecutive patients with severe aortic regurgitation referred for aortic valve surgery were prospectively enrolled in the study.

Exclusion criteria

* history of coronary artery disease * acute aortic valve disease (i.e., type A aortic dissection or infectious endocarditis) * common contraindications for MRI such as severe obesity and metallic foreign bodies.

Design outcomes

Primary

Measure	Time frame	Description
Native T1	baseline (Prior surgery)	Measured with MRI

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026