Multiple Myeloma
Conditions
Keywords
genetic predisposition, mutations, sporadic, multiple myeloma
Brief summary
There is a growing body of data suggesting that the the risk of developing multiple myeloma, or myelomagenesis, is associated with genetic alterations occurring in the tumor cells. A limited number of candidate genes and polymorphisms have been reported in patients with this disease. In this study the investigators will compare the genetic information obtained on purified abnormal plasmocytes obtained from patients with multiple myeloma with available public databases in an effort to identify and if possible validate the role of certain mutations and/or polymorphisms in myelomagenesis. Plasmocytes will be obtained by immunomagnetic enrichment using CD138+ beads.
Interventions
GENETICDNA sequencing
The aim of this study is to perform DNA sequencing on abnormal plasmocytes obtained from patients with multiple myeloma, in order to identify alterations which are associated with the existence of this disease. DNA analyses will be performed in a single experiment once all samples have been collected.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of multiple myeloma * availability of abnormal plasmocytes
Exclusion criteria
\- none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| DNA mutations associated with the existence of multiple myeloma | baseline, pre-intervention/procedure/surgery | DNA data acquired in myeloma patient samples will be compared to those of healthy subjects using publically available databases. |
Countries
France
Contacts
Primary ContactCharles DUMONTET, Pr
Outcome results
None listed