Preterm, Red Blood Cells
Conditions
Brief summary
A cross sectional study to assess the effect of blood transfusions on the outcome of preterm infants
Detailed description
This is a cross sectional study carried on preterm infants who are staying in the hospital as growers; to gain weight. We will assess blood transfusion received by these preterm infants in details.
Interventions
None listed
Sponsors
Kasr El Aini Hospital
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Grower preterm infants
Exclusion criteria
* Severe illness, Hypovolemic shock, Hypoxia, Oxygen therapy, Surgical intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in heart rate | immediately before and immediately after blood transfusion | Heart rate per minute |
| Change in respiratory rate | immediately before and immediately after blood transfusion | Respiratory rate per minute |
| Change in weight gain | within 4 days before and within 4 days after blood transfusion | Average weight gain in grams/kg/day |
| Change in hemoglobin | immediately before and immediately after blood transfusion | Hemoglobin in grams/dl |
| Change in hematocrit value | immediately before and immediately after blood transfusion | Hematocrit value percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tachypnea | in the previous 24 hours before blood transfusion | ≥24 hours of tachypnea (Respiratory rate\>60/minute), |
| Poor weight gain | in the previous 4 days before blood transfusion | ≤10 g/kg/day while the infant is receiving ≥120 kcal/kg/day |
| Metabolic acidosis | in the previous 24 hours before blood transfusion | pH \<7.2 |
| Acute blood loss | in the previous 24 hours before blood transfusion | Acute blood loss either spontaneous or iatrogenic during invasive procedures |
| Length of stay in the NICU | from date of birth until the date of transfer to the grower ward or date of death from any cause, whichever came first, assessed up to 3 months. | Length of stay in the NICU |
| Length of stay in the hospital | from date of birth until the date of discharge home or date of death from any cause, whichever came first, assessed up to 3 months. | Length of stay in the hospital |
| Mortality | from the date of transfer to grower ward, assessed up to 3 months. | Death |
| Apnea and bradycardia | in the previous 24 hours before blood transfusion | 9 episodes or ≥2 episodes requiring bag and mask ventilation, while infant is receiving caffeine citrate |
| Mechanical ventilation | in the previous 24 hours before blood transfusion | Mechanical ventilation (MV) which may be one of two possibilities: 1. Moderate or significant MV; Mean airway pressure (MAP) \>8 cm H2O on conventional ventilator or \>14 cm H2O on high frequency ventilator and FiO2 \>0.4 2. Minimal MV; MAP ≤8 cmH2O on conventional ventilator or ≤14 cm H2O on high frequency ventilator and FiO2 ≤ 0.4 |
| Supplemental oxygen | in the previous 24 hours before blood transfusion | Supplemental oxygen, not mechanically ventilated |
| Doubling of oxygen requirements | in the previous 2 days before blood transfusion | Doubling of oxygen requirements for patients on supplemental oxygen |
| Tachycardia | in the previous 24 hours before blood transfusion | ≥24 hours of tachycardia (Heart rate\>180/minute) |
Contacts
Primary ContactDouaa El Sherbiny, MD
Outcome results
None listed