Acute Kidney Injury, Chronic Kidney Injury, COVID-19
Conditions
Brief summary
To understand the long-term epidemiology, develop effective risk-prediction and stratification tools, and understand the pathobiology of kidney disease in COVID-19 survivors.
Interventions
None listed
Sponsors
New Jersey Medical School
University of Michigan
Yale New Haven Health System Center for Healthcare Solutions
Johns Hopkins University
Icahn School of Medicine at Mount Sinai
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Criteria: Inclusion Criteria: * Adults, age ≥18 years * Confirmed diagnosis of COVID-19
Exclusion criteria
• No confirmed diagnosis of COVID-19
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| estimated Glomerular Filtration Rate (eGFR) | yearly for 4 years after COVID exposure | Kidneys filter blood by removing waste and extra water to make urine. The kidney's filtration rate, called the glomerular filtration rate (GFR), shows how well the kidneys are filtering. A normal GFR is 60 or higher. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Urine Albumin-to-Creatinine Ratio (UACR) | yearly for 4 years after COVID exposure | Albuminuria is present when UACR is greater than 30 mg/g and is a marker for chronic kidney disease. Albuminuria is used to diagnose and monitor kidney disease. |
| Urine protein/creatinine ratio (UPCR) | yearly for 4 years after COVID exposure | Urine protein/creatinine ratio - Protein creatinine ratio in the urine quantifies the loss of the protein and helps in further evaluation of the kidney function. Normal ratio: \< 0.20 |
Countries
United States
Outcome results
None listed