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Effects of Systemic Drugs on Intraocular Pressure

Effects of Two Systemic Drugs on Intraocular Pressure in Narrow Angle Glaucoma

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05328921
Enrollment
200
Registered
2022-04-14
Start date
2022-04-07
Completion date
2022-09-30
Last updated
2022-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Angle-Closure, Glaucoma Suspect, Glaucoma Secondary to Drugs, Bilateral, Hypertension

Keywords

Angle closure glaucoma, Hypertension, Antihistaminic, Antihypertensive

Brief summary

To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

Detailed description

Changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma. In this study we aim to assess changes in intraocular pressure (IOP) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Interventions

Patients with narrow angle glaucoma and on systemic antihypertensive drugs.

DRUGAntihistaminics

Patients with narrow angle glaucoma and on systemic antihistaminic drugs.

Sponsors

Benha University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
35 Years to 70 Years

Inclusion criteria

* patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs.

Exclusion criteria

* open angle glaucoma patients confirmed by gonioscopy examination. * Cases with dense corneal opacity or iris trauma that may affects gonioscopy examination. * cases with secondary glaucoma.

Design outcomes

Primary

MeasureTime frameDescription
Changes in intraocular pressure (IOP) measured by applanation tonometryImmediately after visual acuity assessment for each eye after topical anesthetic eye drops and again on one and three months visitChanges in IOP measured by millimeter mercury (mmHg)

Secondary

MeasureTime frameDescription
Changes in pupil diameterImmediately after slit lamp examination and again on one and three months visitSize of pupil measured in millimeters (mm) 7sing autorefractometer

Countries

Egypt

Contacts

Primary ContactAhmed Abdelshafy, MD
ahmad4lg@gmail.com01222328766
Backup ContactMarwa Abdelshafy, MD
ahmad4lg@gmail.com01222328766

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026