Post-traumatic Headache Multidisciplinary Study

The Effect of Multidisciplinary Intervention on Patients With Persistent Post-traumatic Headache

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05328635

Acronym

PTHMS

Enrollment

Registered

2022-04-14

Start date

2021-09-01

Completion date

2024-09-01

Last updated

2025-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Concussion Syndrome, Post-Traumatic Headache

Brief summary

The study will investigate the effect of pharmacological preventive treatment, education, physiotherapy and psychological counselling on the headache and associated symptoms in patients refered to the Danish Headache Center

Detailed description

Pharmacological interventions are candesartan, amitritylin and gabapentin depending on the headache phenotype. In total 3 visits spanned over 1 year Education is conducted as group sessions of up to 10 patients by two specialist nurses 2 x 90 min Physiotherapy is conducted as group sessions of up to 5 patients by physiotherapists 8 x 60 min plus 2 individual sessions. Psychology is conducted as group sessions of up to 10 patients by psychologist 3x60 min plus option of 1 individual session.

Interventions

DRUGCandesartan

Multdisciplinary approach

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with post-traumatic headache \-

Exclusion criteria

* Medication-overuse headache

Design outcomes

Primary

Measure	Time frame	Description
Change in headache days	1 year	Headache days will be obtained via a validated questionaire
Rivermead post-concussion questionare score	1 year	Rivermead is a validated questionaire to assess concussion symptoms
HADS-scores	1 year	HADS = Hospital anxiety and depression scale. A validated tool to assesss depression and anxiety symptoms
Self-perceived health	1 year	based on EU-SILC validated question on self-perceived health ('How is your health in general?'), which contains five answering categories; 1) very good, 2) good, 3) fair, 4) bad, 5) very bad.
Level of physical activity	1 year	Based on questionaire, where patients can choose: Low level of physical activity: primarily sedentary activities or light exercise at least 4 hours a week, or

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026