Adiposity
Conditions
Brief summary
Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.
Interventions
DIAGNOSTIC_TESTOral Glucose Tolerance Test
Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.
Sponsors
University of Michigan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 18-40 years old * Body Mass Index: 23-35 kg/m2 * Women must have regularly occurring menses and must be premenopausal
Exclusion criteria
* Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism, or inflammation * Weight instability ≥ ± 6 pounds in the last 6 months * Tobacco or e-cigarette users * Women must not be pregnant or actively lactating * Blood pressure \> 140/90 mmHg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Glucose Level | 2 hours at Experimental Trial | mg/dL |
| Adipose tissue fibrosis | baseline | Pico-sirius Red stain (percent stained) |
Countries
United States
Outcome results
None listed