Diarrhea, Infantile
Conditions
Keywords
Vitamin C, Diarrhea, Children
Brief summary
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses, parasites). Diarrhea is one of the main causes of malnutrition in children under five years of age. Inversely, nutritional deficiency, particularly vitamin C deficiency, can be a risk factor for diarrhea. The main objective of this study is to assess the impact of vitamin C deficiency on diarrheal infection in children aged 2 to 5 years in countries with a high diarrheal rate. This pilot case-control study will be conducted in metropolitan France, Africa and South America. This question will be addressed by comparing vitamin C levels in children with diarrhea, regardless of the infectious agent, to levels in age- and sex-matched controls.
Detailed description
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses, parasites). Diarrhea is one of the main causes of malnutrition in children under five years of age. Inversely, nutritional deficiency, particularly vitamin C deficiency, can be a risk factor for diarrhea. The main objective of this study is to assess the impact of vitamin C deficiency on diarrheal infection in children aged 2 to 5 years in countries with a high diarrheal rate. This pilot case-control study will be conducted in metropolitan France, Africa and South America. This question will be addressed by comparing vitamin C levels in children with diarrhea, regardless of the infectious agent, to levels in age- and sex-matched controls. The study aims at (i) determining whether vitamin-deficiency may occurs in children living in developing countries and at (ii) determining the plasma vitamin A, C and E concentrations in children suffering of diarrheal diseases. A total of 360 children will participate to the study.
Interventions
DIAGNOSTIC_TESTBlood sample collection
Blood sample collection for dosage of vitamin C
Sponsors
Institut Pasteur
Institut Cochin
University of Copenhagen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Months to 60 Months
Healthy volunteers
Yes
Inclusion criteria
Controls : Inclusion Criteria: * not suffering of diarrhea * no fever * no sign of infection
Exclusion criteria
: * Suspected or diagnosed infectious diseases * Known genetic diseases * Known diseases that may interfere with iron and/or vitamin C metabolism * Known inflammatory diseases * Malnutrition * Diarrhea * Fever * Positive malaria rapid diagnostic test (Africa) * Child currently being breastfed Chronic diarrhea cases : Inclusion Criteria: -Children suffering from chronic diarrhea defined by the emission of at least 3 soft or liquid stools per day for at least 4 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma levels of vitamin C | 1 year | Plasma levels of vitamin C will be used to determine whether vitamin-deficiency may occurs in children living in developing countries |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma levels of vitamin A, C and E | 1 year | Plasma levels of vitamin A, C and E will be used to determine the plasma vitamin A, C and E concentrations in children suffering of diarrheal diseases |
Countries
Central African Republic, France, New Caledonia
Contacts
PRINCIPAL_INVESTIGATORAlexandre Manirakiza, MD, PhD
Institut Pasteur de Bangui, Centrafrican Republic
PRINCIPAL_INVESTIGATORThomas Blanc, MD, PhD
Hopital Necker Paris, France
PRINCIPAL_INVESTIGATORJean-Chrysostome Gody, MD, PhD
Complexe Pédiatrique de Bangui, Centrafrican Republic
PRINCIPAL_INVESTIGATOREmilie Huguon, MD
Centre Hospitalier Térritorial Gaston Bourret, New Caledonia
Outcome results
None listed