HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

HIF-1 Alpha, VEGF and MMP-8 Levels in Peri-implant Crevicular Fluid of Smokers Versus Non Smokers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05325918

Enrollment

Registered

2022-04-13

Start date

2021-08-29

Completion date

2022-01-30

Last updated

2022-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-Implantitis

Keywords

gingival crevicular fluid, Smoking, inflammation

Brief summary

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Detailed description

Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals. The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Medically free patients * Individuals with restored implants placed one year or more before study enrollment * Both genders * Age range 20-50 years old

Exclusion criteria

* Pregnant Females * Lactating females

Design outcomes

Primary

Measure	Time frame	Description
Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid	Baseline	Markers collected using periopaper strips

Countries

Egypt

Outcome results