Cirrhosis, Liver, Portal Hypertension, Splenectomy; Status
Conditions
Keywords
Cirrhosis, Splenectomy, Azygoportal disconnection, Laparoscopy, Liver Reserve Function
Brief summary
In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.
Detailed description
The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy and azygoportal disconnection, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh, ascites, prealbumin, ICG-K, ICG-R 15 and ICG-T/2.
Interventions
The laparoscopic splenectomy and azygoportal disconnection was performed by the same surgical team.
Sponsors
Northern Jiangsu People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism * gastroesophageal variceal bleeding * Informed consent to participate in the study
Exclusion criteria
* Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Human immunodeficiency virus (HIV) infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver reserve function ICG-T/2 at 12 months after surgery. | 12 months | The level of liver reserve function ICG-T/2 at 12 months after surgery. |
| Liver reserve function ICG-T/2 at 24 months after surgery. | 24 months | The level of liver reserve function ICG-T/2 at 24 months after surgery. |
| Liver reserve function ICG-K at 3 months after surgery. | 3 months | The level of liver reserve function ICG-K at 3 months after surgery. |
| Liver reserve function ICG-K at 6 months after surgery. | 6 months | The level of liver reserve function ICG-K at 6 months after surgery. |
| Liver reserve function ICG-K at 12 months after surgery. | 12 months | The level of liver reserve function ICG-K at 12 months after surgery. |
| Liver reserve function ICG-K at 24 months after surgery. | 24 months | The level of liver reserve function ICG-K at 24 months after surgery. |
| Liver reserve function ICG-R 15 at 3 months after surgery. | 3 months | The level of liver reserve function ICG-R 15 at 3 months after surgery. |
| Liver reserve function ICG-R 15 at 6 months after surgery. | 6 months | The level of liver reserve function ICG-R 15 at 6 months after surgery. |
| Liver reserve function ICG-R 15 at 12 months after surgery. | 12 months | The level of liver reserve function ICG-R 15 at 12 months after surgery. |
| Liver reserve function ICG-R 15 at 24 months after surgery. | 24 months | The level of liver reserve function ICG-R 15 at 24 months after surgery. |
| Liver reserve function ICG-T/2 at 3 months after surgery. | 3 months | The level of liver reserve function ICG-T/2 at 3 months after surgery. |
| Liver reserve function ICG-T/2 at 6 months after surgery. | 6 months | The level of liver reserve function ICG-T/2 at 6 months after surgery. |
Countries
China
Contacts
Primary ContactGuo-Qing Jiang, MD
Backup ContactDou-Sheng Bai, MD
Outcome results
None listed