Neurosciences
Conditions
Brief summary
This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.
Detailed description
Despite ongoing progress in the understanding of social behavior, little is known about the single-neuronal mechanisms that underlie human social cognition. The investigators will obtain single-neuronal recordings from the prefrontal cortex in participants undergoing clinically planned deep brain stimulation (DBS) electrode placement. The study population will consist of subjects undergoing planned DBS placement. Prospective participants will be selected for surgery irrespective of their participation in the study. After consenting to the study, the participants will be allowed to withdraw from participation at any time. No control subjects will be used. Instead, each subject will act as their own control based on task performance. For the study, neuronal recordings will be integrated within planned neurosurgical care and will be obtained from the prefrontal cortex as participants perform a brief behavioral task. During recordings and prior DBS placement, the participants are normally asked to make movements or answer questions based on verbal cues to aid in targeting the correct areas. The participants will be additionally asked to perform a brief linguistic-based task in which scenarios containing social agents are presented to the participants and in which they have to verbally describe/answer questions about them. Following cortical recordings and stimulation, the standard clinical procedure and DBS electrode placement proceeds as planned. The neuronal and behavioral data will then be analyzed off-line.
Interventions
BEHAVIORALBehavioral testing during neuronal recordings
Participants undergoing clinically planned neurosurgical procedures will undergo single-neuronal recordings as they perform brief behavioral tasks.
Sponsors
Massachusetts General Hospital
Brown University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Human subjects undergoing clinically planned neurosurgical procedures
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. 18 years old or older 2. patients able to give informed consent
Exclusion criteria
1. Children under 18 2. Significant co-morbidities 3. Claustrophobia or general anxiety that may impact intraoperative testing 4. Use of CNS-active medications including stimulants and antipsychotics which may alter 5. Pregnancy 6. Operative events that will require expedition of the surgery. 7. Poor tolerance of testing by the patient 8. Increased abnormal cortical excitability 9. Necessity to administer drugs that will interfere with mapping
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of neurons displaying changes in activity related to task events | 15 minutes | Neuronal signals will be recorded during performance of a language-based social task over a 15 minute period. A multinomial logistic regression analyses will be used to evaluate for changes in neuronal activity that are associated with social versus non-social task events. Neuronal activity will be measured as the number of spikes recorded during each event, with each event lasting for approximately one second. Significance threshold will be set to p \< 0.01. The primary outcome measure will be the proportion of neurons that reach significance threshold and therefore display task-related modulation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of task events that can be correctly predicted from neuronal activity | 15 minutes | Neuronal signals will be recorded during performance of a language-based social task over a 15 minute period. Support vector machines will be used to determine whether changes neuronal activity can accurately predict the participants task performance. Neuronal activity will be measured as the number of spikes recorded during each question-answer event, with each event lasting for approximately one second. Significance threshold will be set to p \< 0.01. The primary outcome measure will be the percentage of events that are predicted correctly. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORZiv Williams, MD
Massachusetts General Hospital
Outcome results
None listed