Thyroid Cancer, Thyroid Nodule
Conditions
Keywords
thyroid cancer, thyroid nodule, miRNA, molecular testing
Brief summary
Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. Obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.
Detailed description
This is an non-randomised retrospective study consisting of 2 parts. Part A. Histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of Belarusian population. Part B. Fixed cytological smears of indeterminate thyroid nodules (categories III, IV and V according to Bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.
Interventions
DIAGNOSTIC_TESTMolecular testing
Molecular testing of thyroid nodules
Sponsors
The Institute of Genetics and Cytology National Academy of Sciences of Belarus
Minsk City Clinical Oncologic Centre
Belarusian State Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients operated on for malignant and benign thyroid tumors. Age is greater than or equal to 18 years old.
Exclusion criteria
no
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Molecular profile of thyroid nodules | 2 years | To develop a molecular profile of thyroid nodules that will allow to distinguish benign from malignant tumor |
Contacts
Primary ContactSiarhei U Yakubouski, MD PhD
Outcome results
None listed